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CXXC4


Official Full Name
CXXC finger protein 4
Organism
Homo sapiens
Gene ID
80319
Background
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Synonyms
IDAX

Cat.No. Product Name Price
SHH272469 shRNA set against Mouse CXXC4 (NM_001004367.4) Inquiry
SHH272465 shRNA set against Human CXXC4 (NM_025212.2) Inquiry
SHH272473 shRNA set against Rat CXXC4 (NM_053342.2) Inquiry
Cat.No. Product Name Price
MiUTR3H-12026 CXXC4 miRNA 3'UTR clone Inquiry
CDCB191228 Rabbit CXXC4 ORF clone (XM_002717203.2) Inquiry
CDCR380185 Rat Cxxc4 ORF Clone(NM_053342.2) Inquiry
CDCS415931 Human CXXC4 ORF Clone (BC119751) Inquiry
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