Pages
Products

CHRNA7


Official Full Name
cholinergic receptor nicotinic alpha 7 subunit
Organism
Homo sapiens
Gene ID
1139
Background
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Synonyms
NACHRA7; CHRNA7-2

Cat.No. Product Name Price
SHG177301 shRNA set against Mouse Chrna7(NM_007390.3) Inquiry
SHH263601 shRNA set against Mouse CHRNA7 (NM_007390.3) Inquiry
SHG177319 shRNA set against Rat Chrna7(NM_012832.3) Inquiry
SHH263597 shRNA set against Human CHRNA7 (NM_000746.5) Inquiry
SHH263605 shRNA set against Rat CHRNA7 (NM_012832.3) Inquiry
SHW004698 shRNA set against Chicken CHRNA7 (NM_204181) Inquiry
SHW017317 shRNA set against Danio rerio CHRNA7 (NM_201219) Inquiry
Cat.No. Product Name Price
OE-PNDC000297 Human CHRNA7 Nanodisc Inquiry
Cat.No. Product Name Price
CDFR010688 Rat Chrna7 cDNA Clone(NM_012832.3) Inquiry
MiUTR1H-02146 CHRNA7 miRNA 3'UTR clone Inquiry
MiUTR1M-03022 CHRNA7 miRNA 3'UTR clone Inquiry
MiUTR1R-00986 CHRNA7 miRNA 3'UTR clone Inquiry
CDCB166173 Chicken CHRNA7 ORF Clone (NM_204181) Inquiry
CDCB178792 Danio rerio CHRNA7 ORF Clone (NM_201219) Inquiry
CDCB191915 Rabbit CHRNA7 ORF clone (XM_002718287.2) Inquiry
CDCR243537 Mouse Chrna7 ORF Clone(NM_007390.3) Inquiry
CDCR377691 Rat Chrna7 ORF Clone(NM_012832.3) Inquiry
CDCS405876 Human CHRNA7 ORF Clone (BC037571) Inquiry
Quick Inquiry