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ABCC8


Official Full Name
ATP binding cassette subfamily C member 8
Organism
Homo sapiens
Gene ID
6833
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations in the ABCC8 gene and deficiencies in the encoded protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]
Synonyms
ATP1B

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AD00302Z ABCC8 adenovirus Inquiry
AD00461Z Human ABCC8 adenoviral particles Inquiry
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SHH229178 shRNA set against Mouse ABCC8 (NM_011510.3) Inquiry
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SHH229174 shRNA set against Human ABCC8 (NM_000352.3) Inquiry
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CDCB192768 Rabbit ABCC8 ORF clone (XM_008275110.1) Inquiry
CDCR377921 Rat Abcc8 ORF Clone(NM_013039.2) Inquiry
CDFR010844 Rat Abcc8 cDNA Clone(NM_013039.2) Inquiry
MiUTR1H-00043 ABCC8 miRNA 3'UTR clone Inquiry
MiUTR1M-01045 ABCC8 miRNA 3'UTR clone Inquiry
CDCB175057 Danio rerio ABCC8 ORF Clone (NM_001172647) Inquiry
CDCR022972 Human ABCC8 ORF clone (NM_000352.3) Inquiry
CDCR250834 Mouse Abcc8 ORF Clone(NM_011510.3) Inquiry
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