Optogenetic, a recently developed technology has been commonly used in the field of neuroscience. It is a neuro modulation method that uses a combination of techniques from optics and genetics to control and monitor the activities of individual neurons in living tissue, even in a freely-moving animal. This technology allow us to achieve an unprecedented understanding of neural circuit function, such as neural circuit dysfunction underlying mood disorders, addiction, Parkinson’s disease, and the neural circuits mediating normal behavior.
In this technology, neurons are first genetically engineered to express a light-sensitive protein (opsin), which is typically an ion channel, pump, or G protein–coupled receptor. When these engineered neurons are then illuminated with light of the correct frequency they will be transiently activated or inhibited or their signaling pathways will be modulated, depending on the particular kind of opsin that was chosen for expression.
Creative Biogene can offer you with various optogenetic tool vectors that can express different opsins to meet your specific needs. Besides, Creative Biogene also can provide you with related service, AAV packaging service, to accelerate the speed to achieve your research goals.