As a biochemical process, in which a methyl group is added to the cytosine or adenine DNA nucleotides, DNA methylation is a key epigenetic modification to cytosines, usually in CpG dinucleotides, frequently associated with gene silencing. Besides, DNA methylation can smoothly change the expression of genes in cells while cells divide and differentiate from embryonic stem cells into specific tissues. As a result, the related change is unidirectional as well as permanent.
On the other hand, during zygote formation process, DNA methylation is removed and re-established by successive cell divisions. But as some research shows recently, hydroxylation of methyl groups occurs instead of complete removal of methyl groups in the zygote. Additionally, the rate of cytosine DNA methylation is different because of different species.
As is also known that genome-wide DNA methylation analysis is more easily to be carried out through using Creative Biogene’s excellent and comprehensive DNA methylation analysis services. Creative Biogene provides platform, which always results in reliable information on the methylation states of individual cytosines by effectively and efficiently preparing converted DNA for use in next generation sequencing techniques. What’s more, the study of methylation at single base resolution of individual cytosines in DNA is facilitated by bisulfite treatment of DNA followed by PCR amplification, cloning, and sequencing of individual amplimers. And the most reliable and accurate data is delivered to the clients during the experiments in a timely manner. Scientists at Creative Biogene are committed themselves to the rapid development of life science.
To sum up, Creative Biogene, one of the most reliable biotech companies worldwide, will try its best to help each client to speed up work, making a promise to delivery the best services and products within the shortest turnaround time. Therefore, each customer of Creative Biogene can skip the technical hurdles, focusing more on the biology your research, and expedite end-results.
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Tags: DNA, DNA Methylation Analysis, Creative Biogene