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Custom Gene Knockdown Cell Lines

email info@creative-biogene.com Tel: 1-631-626-9181 Fax: 1-631-614-7828

RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecules. It is a valuable research tool because synthetic dsRNA introduced into cells can selectively and robustly induce suppression of specific genes of interest. RNAi may be used for large-scale screens that systematically shut down each gene in the cell, which can help to identify the components necessary for a particular cellular process or an event such as cell division. The pathway is also used as a practical tool in biotechnology, medicine and insecticides.

shRNA is an advantageous mediator of RNAi in that it has a relatively low rate of degradation and turnover. Creative Biogene offers the generation of cell lines stably expressing shRNAs targeting a gene of interest. We will design your shRNAs and integrate them into virtually any cell line you choose.


Custom Gene Knockdown Cell Lines


Our services include:

  • Construct generation
  Synthesis and cloning of shRNA constructs targeting gene of interest into a suitable mammalian expression vector
  or a lentiviral vector followed by producing high titer lentivirus. Based on your requirements we choose
  the best strategy and corresponding vector system.
  • Stable cell clones selection
   Perform transfection or transduction on target cells and select stable cell clones.
  • Validation
  Validation RNAi gene silencing by real-time qRT-PCR and/or Western blot.

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  Order Info: Custom Gene Knockdown Cell Lines  order info
Services
Contact us to order
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828
Email: info@creative-biogene.com
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CONTACT US TO ORDER


CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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