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Transporter Screening & Profiling Services

email info@creative-biogene.com Tel: 1-631-626-9181 Fax: 1-631-614-7828

Brief Introduction


Creative Biogene is a leading biotechnology company in the field of transporters screening and profiling services. With years of experience and innovation of transporters compounds assays, we can offer a wide range of targets coverage to help you fulfill transporters drug discovery project effectively and high-quality.

Creative Biogene has built various platforms to overcome the challenges associated with transporter assays. We offer a broad of transporter screening assays, including FDA transporter panel, monoamine transporter models and many other cell models. Moreover, Creative Biogene has developed robust transporters uptake and inhibition assays to allow screening of new molecular entities (NMEs) for their interactions with transporters quickly and effectively.

Transporters are a kind of membrane proteins controlling uptake and efflux of essential nutrients ions, neurotransmitters, cellular waste, environmental toxins, and drugs, into and out of cells and organelles. Therefore, transporters play a significant important role in drug's clinical efficacy and safety. Currently, transporters are used as therapeutic targets to treat numerous diseases such as diabetes, asthma, cardiovascular diseases, major depression, neuroscience, hypertension and constipation.

In human genome, more than 400 membrane transporters are annotated. Generally, membrane transporters are divided into two major super-families, the ATP binding cassette (ABC) family and the solute carrier (SLC) family. Preclinical and clinical studies indicate that transport is an important determinant of drug disposition, as well as therapeutic and adverse drug effects (KM, et al. 2013).

Transporter Screening & Profiling Services Fig.1 The Structure of ABC transporter

Creative Biogene offers various platforms and detection formats for transporter drug discovery, including but not limited to the following categories:

  1. Fluorescence detection
  2. Radioactivity detection
  3. Electrophysiology

Advantages of transporters screening and profiling in Creative Biogene:

  1. Providing functional characterization of compound activity by cell based assays
  2. Key drug transporters are covered
  3. Drug transporter assays meet various requirements
  4. Short turn-around time

Creative Biogene offers availability of various panels for screening and profiling of transporters compounds. Our experienced and talented scientists are dedicated to help you identify the compounds with the greatest chance to success. Creative Biogene has delivered a plenty of services to meet your demands of transporters compounds screening. We are confident in accelerating your drug discovery projects and providing you results with fast turnaround time and high-quality.

If you have any special requirements in transporters compound screening, please feel free to contact us at info@creative-biogene.com or 1-631-626-9181. We are looking forward to working together with your attractive projects.

Reference:

  1. KM, G., and S-M, H. (2013) ‘Transporters in Drug Development and Clinical Pharmacology’, Clinical pharmacology & Therapeutics, 94(1), 3-9
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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email:info@www.creative-biogene.com
Europe
Tel: 44-207-048-3343

Email:info@www.creative-biogene.com
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CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-048-3343

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