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Nuclear Receptor Screening & Profiling Services

email info@creative-biogene.com Tel: 1-631-626-9181 Fax: 1-631-614-7828

Creative Biogene is offering a comprehensive screen of cellular and biochemical nuclear receptor assays to profile your compounds. Measurements of ligand binding activity, NRs translocation, and NR-coregulator interaction are included to characterize the selectivity and potential off-target events. With our extraordinary experience in drug discovery programs targeting nuclear receptors, our scientists are able to help you accelerate your research program and significantly increase your chance of reaching success.

Nuclear Receptor Screening & Profiling Services Fig.1 The sketch of nuclear receptor

Creative Biogene offers a broad portfolio of assays to meet your project objectives. Our comprehensive nuclear receptor assays are including HTS, IC50 determination and selectivity, glucocorticoid receptor, progesterone receptor, androgen receptor, mineralocorticoid receptor, ror gamma t receptor, estrogen receptor, retinoic acid receptor binding and profiling assays. Other than existing assays, Creative Biogene has also developed customized assays for the clients. Our nuclear receptor experts can provide the highest quality data under rapid turnaround time evaluating your compounds’ efficacy, potency, and selectivity to make the critical decisions regarding compound liabilities. If you plan to set up a nuclear receptor screening and profiling program, we are here to help.

Nuclear receptors (NRs) are a class of proteins responsible for sensing steroid and thyroid hormones and certain other molecules. There are 48 genes in the human genome that code for the NRs. The myriad molecular pathways modulated by NRs including but not limited to inflammation, lipid metabolism, apoptosis, extracellular matrix regulation, energy metabolism, and angiogenesis. These pathways’ processes can impact human health, such as general homeostasis, growth, and proliferation, which enable NRs to become the important therapeutic targets in the pathology of cancer, inflammation, and many other diseases for decades.

Nuclear Receptor Screening & Profiling Services Fig.2 Phylogenetic tree of human nuclear receptors

Advantages of nuclear receptor profiling in Creative Biogene:

  1. Screening and profiling of a broad range of nuclear receptors
  2. Information on an essential family of receptors responsible for a wide range of on- and off-target biological processes
  3. Our unparalleled expertise and cutting-edge know-how create an unprecedented and extremely competitive integrated NR drug discovery platform

With years of expertise in this field, Creative Biogene is dedicated to ensuring all services and results of nuclear receptor screening and profiling are at the highest level of quality. For the last 10 years, Creative Biogene has delivered a plenty of services that meet the requirements of nuclear receptor compound screening. We are confident in accelerating your experimental progress and achieving ideal research goals with the most competitive price.

If you have any special requirements in Nuclear Receptor compound screening, please feel free to contact us at info@creative-biogene.com or 1-631-626-9181. We are looking forward to working together with your attractive projects.

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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email:info@creative-biogene.com
Europe
Tel: 44-207-048-3343

Email:info@creative-biogene.com
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CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-048-3343

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