Creative Biogene is the leading company offering a wide range of ion channel services in this field. We have developed an extensive ion channel screening and profiling assays for variety ion channel types. The goal of our services is to efficiently save your time during your drug discovery project with the most competitive price.
Creative Biogene provides broad types of ion channel services and ion channel cell lines, including but not limited to the following categories:
Voltage-gated sodium channels are vital targets for excitable diseases treatment, such as epilepsy and neuropathic pain. They are present in the membrane of most excitable cells and comprise of one pore-forming α subunit associated with one or two β subunits. It has been known that there are nine members in the family of sodium channels, namely Nav1.1 to Nav1.9, and most of them were found mainly in the central nervous system, peripheral neurons and dorsal root ganglia. In addition, Nav1.5 is primarily found in cardiac myocytes while Nav1.4 is located in skeletal muscle.
Calcium channels are found in excitable cells such as muscle and neurons and consist of a α1 ion-conducting pore which forms a complex with associated subunits (α2δ, β1-4, γ). Voltage-gated calcium channel α1 contains several various subtypes, namely the L-type (including Cav1.1, 1.2, 1.3, and 1.4), P/Q-type (Cav2.1), N-type (Cav2.2), R-type (Cav2.3) and T-type (Cav3.1, 3.2. 3.3) channels (Wienecke, et al. 2010).
Potassium-selective channels are the largest and most diverse group among the ion channel families. The classes of channels include voltage-gated (Kv), inward-rectifying (KIR), two-pore (K2P) and Ca2+ -activated (KCa) potassium channels. Potassium channels Kv11.1 (hERG) and Kv7.1 (KCNQ1) are particular importance in the field of drug safety, as they are associated with the potentially fatal Long QT Syndrome.
Fig.1 Diagram of high-throughput screening methods (Haibo et al. 2016)
Transient receptor potential channels (TRP channels) contain more than 30 ion channels and can be divided into 6 families: TRPML (mucolipin), TRPC (canonical), TRPM (melastatin), TRPV (vanilloid), TRPP (polycystic) and TRPA (ankyrin). TRP channels are found in the entire body and mediate a variety of sensations including taste, vision, pain and extreme temperatures. In addition, they are activated by a wide range of molecules including allicin, capsaicin and menthol.
P2X receptors are a kind of cation-permeable, ligang-gated ion channels that response to the binding of extracellular adenosine 5'-triphosphate (ATP). P2X receptors contain 7 known P2X subunits (P2X1-P2X7), and each of them is capable of forming functional heteromeric or homomeric receptors. P2X receptors were a part of larger family receptors known as the purinergic receptors, and have been indicated to play an important role in inflammation, nociception and airway hyperactivity.
In addition to voltage-gated sodium, calcium and potassium channels and ligand-gated TRP channels, a series of other ion channel families play pivotal roles in health and disease, including hyperpolarization-gated ion channels (HCN), chloride channels (e.g. anoctamins), acid-sensing ion channels (ASIC), and other ligand-gated channels (e.g. GABA-A, nicotinic and NMDA receptors).
With years of experience and expertise in this filed, Creative Biogene will provide the most professional and outstanding ion channel service with different types. We are dedicated to ensuring our services in different channels are at the highest level of quality. Creative Biogene is confident in saving your time and cost to meet your strict project timelines.
If you have any special requirements in our different channel type service, please feel free to contact us at email@example.com or 1-631-626-9181. We are looking forward to working together with your attractive projects.
1.Haibo, Y., Min, L., Weiping, W., Xiaoliang W. (2016) ‘High throughput screening technologies for ion channels’, Acta Pharmacologica Sinica, 37, 34-43
2.Wienecke, J., Westerdahl, A.C., Hultborn, H., Kiehn, O., Ryge, J. (2010) ‘Global Gene Expression Analysis of Rodent Motor Neurons Following Spinal Cord Injury Associates Molecular Mechanisms With Development of Postinjury Spasticity’, J Neurophysiol, 103, 761-778