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GPCR Stable Cell Lines

email info@creative-biogene.com Tel: 1-631-626-9181 Fax: 1-631-614-7828

GPCR (G protein-coupled receptors), are important proteins in cell signaling, with the ability to bind the nucleotides guanosine triphosphate (GTP) and guanosine diphosphate (GDP). GPCR are the largest and most diverse group of membrane receptors in eukaryotes, and play a role in an incredible array of functions in the human body, from sensation to growth to hormone responses. The findings suggest that the topological conformation of GPCR is a seven-transmembrane domain. When the ligand outside the membrane interacts with GPCR, part of the receptor inside the membrane activate a nearby G protein through binding and interaction, and thus initiate different signal transduction pathways, as well as various biological effects.

GPCR Stable Cell Lines

The key point for new drugs research and development is to find, identify and prepare the drug targets. In more than 500 drug targets which have been discovered, GPCR occupy the majority, approximately 50%. Increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third and one-half of all marketed drugs act by binding to GPCR. GPCR have been widely used to screen drugs and study the etiology and pathogenesis of autoimmune diseases. So it’s necessary for researchers to build GPCR stable over-expressing cell lines.

Creative Biogene has professional research team and advanced technological platform, and can provide a series of GPCR over-expressing cell lines to meet all your needs. So far, Creative Biogene has successfully constructed GPCR over-expressing stable cell lines of various species, which has become one of the world's largest banks of GPCR cells. These cell lines have been verified in the functionality and stability through reporter gene assay or intracellular calcium assay, to satisfy our customers’ requirements for screening GPCR-target drugs and final evaluation.

Applications
• Study the specific interactions between GPCRs and their ligands, to better reveal the mechanism of cell signaling.
• Construct cell models for high throughput drugs screening to discover the etiology and pathogenesis of autoimmune diseases and provide a solution.

Advantages
One-stop service: Customized cell generation project was managed by experienced scientists throughout the process, from construction design to drug screening.
Experienced: Creative Biogene has professional research team with experience of many years in the field of molecular and cell biology.
Broad cell types: Creative Biogene has successfully constructed GPCR over-expressing stable cell lines with 293, CHO, HeLa, 1321N1, U2OS, RH7777 etc.
Genetic stability: Our GPCR over-expressing cell lines have been rigorously tested and validated for at least 10 passages continous culture without significant change in assay window.
High Quality: Our GPCR over-expressing cell lines have no mycoplasma contamination.
Cost & Time saving: There are a lot of choices for premade GPCR stable cells enabling for long-term screening, and ready-to-assay/division-arrested GPCR cells suitable for small scale screening assays.

Table 1. Frequently Requested - GPCR Stable Cell Lines
(Gene official symbol listed from A to Z, h: human, r: rat)

hADCYAP1R1
hADORA1
hADORA2A
hADORA2B
hADORA3
hADRA1A
hADRA1B
hADRA1D
hADRA2A
hADRA2B
hADRA2C
hADRB1
hADRB2
hADRB3
hADRBK2
hAGTR1
hAPLNR
hAPLNR
hAVPR1A
rAvpr1a
hAVPR1B
hAVPR2
hBDKRB1
hBDKRB2
hBRS3
hC3AR1
hC5AR1
hCALCR
hCALCRL
hCASR
hCCKAR
hCCKBR
hCCR1
hCCR10
hCCR2
hCCR3
hCCR4
hCCR5
hCCR6
hCCR7
hCCR8
hCCR9
hCHRM1
hCHRM2
hCHRM3
hCHRM4
hCHRM5
hCMKLR1
hCNR1
hCNR2
hCRHR1
hCRHR2
hCX3CR1
hCXCR1
hCXCR2
hCXCR3
hCXCR4
hCXCR5
hCXCR6
hCYSLTR1
hCYSLTR2
hDRD1
hDRD2
hDRD3
hDRD4
hDRD5
hEDNRA
hEDNRB
hF2RL1
hFFAR2
hFFAR3
hFPR1
hFPR2
hFSHR
hGABBR1
hGALR1
hGALR2
hGCGR
hGHRHR
hGHSR
hGIPR
hGLP1R
hGLP2R
hGNRH1
hGNRHR
hGPBAR1
hGPR119
hGPR39
hGPR68
hGRM1
hGRM2
hGRPR
hH3F3A
hHCAR2
hHCRTR1
hHCRTR2
hHRH1
hHRH2
hHRH3
hHTR1A
hHTR2A
hHTR2B
hHTR2C
hHTR4
hHTR6
hHTR7
hKISS1R
hLPAR1
hLPAR2
hLPAR3
hLPAR5
hLTB4R
hMC2R
hMC3R
hMC4R
hMC5R
hMCHR1
hMCHR2
hMLNR
hMRGPRD
hMRGPRX1
hMRGPRX2
hMTNR1A
hNMBR
hNMUR1
hNMUR2
hNPBWR1
hNPSR1
hNPY2R
hNPY4R
hNTSR1
hO3FAR1
hOPRD1
hOPRK1
hOPRL1
hOPRM1
hOXGR1
hOXTR
hP2RY1
hP2RY11
hP2RY12
hP2RY2
hP2RY4
hPPYR1
hPRLHR
hPROKR1
hPROKR2
hPTAFR
hPTGDR
hPTGDR2
hPTGER1
hPTGER2
hPTGER3
hPTGER4
hPTGFR
hPTGIR
hPTH1R
hPTH2R
hQRFPR
hQRFPR
hS1PR1
hS1PR2
hS1PR3
hS1PR4
hS1PR5
hSCTR
hSSR2
hSSTR1
hSSTR2
hSSTR3
hSSTR4
hSSTR5
hSUCNR1
hTACR1
hTACR2
hTACR3
hTBXA2R
hTRHR
hTSHR
hUTS2R
hVIPR1
hVIPR2
hXCR1
 

 

Table 2. Available For Ready-To-Assay/Division-Arrested GPCR Cells
(Gene official symbol listed from A to Z, h: human, m: mouse, r: rat, d: dog)

hADCYAP1R1
hADORA1
hADORA2A
hADORA2B
rAdora2b
hADORA3
hADRA1A
hADRA1B
hADRA1D
hADRA2A
hADRA2B
hADRA2C
hADRB1
hADRB2
hADRB3
hADRBK2
hAGTR1
hAPLNR
hAPLNR
hAVPR1A
hAVPR1B
hAVPR2
hBDKRB1
hBDKRB2
hBRS3
hC3AR1
hC5AR1
hCALCR
hCALCRL
hCASR
rCasr
hCCKAR
hCCKBR
hCCR1
hCCR10
hCCR2
hCCR3
hCCR4
hCCR5
hCCR6
mCcr6
hCCR7
hCCR8
hCCR9
mCcr9
dCcr9
rCcr9
hCHRM1
hCHRM2
hCHRM3
hCHRM4
hCHRM5
hCMKLR1
hCNR1
hCNR2
hCRHR1
hCRHR2
hCX3CR1
hCXCR1
hCXCR2
hCXCR3
hCXCR4
hCXCR5
hCXCR6
hCXCR7
hCYSLTR1
hCYSLTR2
hDRD1
hDRD2
hDRD4
hDRD5
hEDNRA
rEdnra
hEDNRB
hF2R
hF2RL1
hFFAR1
rFfar1
mFfar1
hFFAR2
rFfar2
mFfar3
hFFAR3
rFfar3
hFPR1
hFPR2
hFSHR
hGABBR1
hGALR1
hGALR2
hGCGR
hGHRHR
mGhsr
hGHSR
hGIPR
hGLP1R
hGLP2R
hGNRH1
hGNRHR
rGpbar1
hGPBAR1
mGpbar1
hGPR119
hGPR142
mGpr183
hGPR3
hGPR35
hGPR37L1
hGPR39
hGPR50
hGPR55
hGPR68
hGPR84
hGRM1
hGRM2
hGRM3
rGrm4
hGRM4
mGrm4
hGRM5
hGRM6
hGRM7
hGRM8
hGRPR
hH3F3A
hHCAR2
hHCAR3
hHCRTR1
hHCRTR2
hHRH1
hHRH2
hHRH3
mHrh3
hHRH4
mHrh4
hHTR1A
hHTR1B
dHTR2A
hHTR2A
hHTR2B
hHTR2C
hHTR4
hHTR6
hHTR7
rKiss1r
hKISS1R
hLPAR1
hLPAR2
hLPAR3
hLPAR4
hLPAR5
mLpar5
hLTB4R
hLTB4R2
hMC2R
hMC4R
hMC5R
rMchr1
hMCHR1
hMCHR2
hMLNR
hMRGPRD
hMRGPRX1
hMRGPRX2
hMTNR1A
hMTNR1B
mMtnr1b
rNmbr
hNMBR
hNMUR1
hNMUR2
hNPBWR1
rNpbwr1
hNPBWR2
mNpsr1
hNPSR1
hNPY1R
hNPY2R
rNpy2r
hNPY5R
hNTSR1
hO3FAR1
rO3far1
mO3far1
rOprd1
hOPRD1
rOprk1
hOPRK1
hOPRL1
rOprl1
rOprm1
hOPRM1
hOXGR1
hOXTR
hP2RY1
hP2RY11
rP2ry12
hP2RY12
hP2RY13
hP2RY14
hP2RY2
rP2ry2
hP2RY4
hP2RY6
hPPYR1
hPRLHR
hPROKR1
hPROKR2
hPTAFR
hPTGDR
hPTGDR2
hPTGER1
hPTGER2
hPTGER3
hPTGER4
hPTGFR
hPTGIR
hPTH1R
hPTH2R
hQRFPR
hRXFP1
hRXFP3
hS1PR1
hS1PR2
hS1PR3
hS1PR4
hS1PR5
hSCTR
hSMO
hSSR2
hSSTR1
hSSTR2
hSSTR3
hSSTR4
hSSTR5
hSUCNR1
rTaar1
hTAAR1
hTACR1
hTACR2
hTACR3
hTBXA2R
hTRHR
rTshr
hTSHR
hUTS2R
rUts2r
hVIPR1
hVIPR2
hXCR1
 
 
 
 
 
 

 

GPCR Stable Cell Lines Products List

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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email:info@creative-biogene.com
Europe
Tel: 44-207-048-3343

Email:info@creative-biogene.com
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CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-048-3343

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