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Human SRF Prom/Luciferase/Hyg Reporter Stable Cell Line-HeLa

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Cat.No.
CSC-RR0035
Background
Serum response factor (SRF) is a widely expressed transcription factor involved in the expression of genes linked to cellular growth and muscle differentiation. Its target genes include cellular immediate early genes such as c-fos and structural cytoskeletal proteins, such as actins, myosins, tropomyosin, and vinculin. Serum-induced transcriptional activation of immediate early genes involves the formation of a ternary complex of SRF with a 62 kDa ternary complex factor (TCF) which binds to the serum response element (SRE). SRF is also involved in vascular smooth muscle differentiation by regulating the expression of several contractile and cytoskeletal genes. It is widely accepted that normal smooth muscle cells are subverted to one of growth and excess matrix production in various disease.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Stability
Cells will undergo genotypic changes resulting in reduced responsiveness over time in normal cell culture conditions. Genetic instability is a biological phenomenon that occurs in all stably transfected cells. Therefore, it is critical to prepare an adequate number of frozen stocks at early passages.
Ship
Dry ice
Gene Information
Official Symbol
SRF
Synonyms
SRF; serum response factor (c-fos serum response element-binding transcription factor); serum response factor; MCM1;
Gene ID
MIM
UniProt ID
P11831
Chromosome Location
6p
Pathway
Coregulation of Androgen receptor activity, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Heart Development, organism-specific biosystem; Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; contributes_to RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; RNA polymerase II transcription factor binding transcription factor activity; chromatin binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; serum response element binding; transcription factor binding;
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Fax: 1-631-614-7828
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Email: info@creative-biogene.com
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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